Category C—May be less safe than than other SSRIs. Associated with cardiac malformations with high-dose, first-trimester use (other studies failed to replicate)
RID 0.5-2.8%; ∅AE's have been reported for majority of paroxetine-exposed infants
↓ clearance in the elderly; lower starting dose is recommended
Significantly affected by severe renal disease (CrCl < 30 ml/min), 4-fold ↑'s in plasma concentrations have been reported
Initial dosage should be reduced in patients with severe hepatic impairment
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Last updated August 15 2022 20:48:12. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.