Class: SNRI FDA Indications: MDD Off-Label Use: Anxiety
Forms: 20, 40, 80, 120mg extended-release capsule Dose Range: 40-120 mg/day Starting: 20 mg qd x2 days, then 40 mg qd; may ↑ by 40 mg/day q2 days.
Stopping: A gradual reduction in the dose rather than abrupt cessation is recommended whenever possible
Contraindications: Concomitant use of MAOIs; uncontrolled narrow angle glaucoma Serious Side Effects: Serotonin syndrome; ↑ risk of SI in children and young adults; may impair platelet aggregation; SIADH; HTN (~3mmHg ↑ in both systolic & diastolic), ↑ HR Side Effects: urinary retention, hyponatremia, nausea, constipation, vomiting, palpitations, erectile dysfunction, anorgasmia, hyperhidrosis
1° MOA: Serotonin norepinephrine reuptake inhibitor Target: SERT, NET
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