Category B—There are insufficient data to identify risks related specifically to clozapine use during pregnancy.
It may be concentrated in the breast milk; however, RID is unknown. Given the severity of adverse events associated with clozapine exposure in adults, its use should be reserved for those with treatment-refractory illness, and monitoring of white blood cell counts in the nursing infant is mandatory
All atypicals may increase mortality in elderly patients by 1.7 times greater than placebo. In the older adult, the titration may need to be slower, and maintenance doses are typically in the 100 to 150 mg/day range.
2019 BEE℞S Recommendation: Avoid, except in schizophrenia or bipolar disorder. Increased risk of CVA and greater rate of cognitive decline and mortality in persons with dementia. Avoid antipsychotics for behavioral problems of dementia or delirium unless nonpharmacological options have failed or are not possible and the older adult is threatening substantial harm to self or others.
There are no dosage adjustments required
There are no dosage adjustments required
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Last updated August 15 2022 20:48:12. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.