Category C—No ↑ risk of major congenital malformations (0.9% in exposed group vs. 2.6% in control). There is an ↑ risk of admission to neonatal ICU
RID 3-10.9%
Pharmacokinetics are altered (~30% ↓ clearance) in patients >60; max dose of 20 mg/day is recommended due to risk of QT prolongation
Moderate renal disease ↑'d t½ from 37° to 49°
Maximum dose 20 mg qd due to ↓ clearance & ↑ QT risk (avg t½ 83° in cirrhotic patients)
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Last updated August 15 2022 20:48:12. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.