Category C—Teratogenic and embryotoxic in one animal species, but human pregnancy data are too limited for a better assessment of the embryo-fetal risk. Complex cardiac defects were reported in three cases, and five other outcomes involved various malformations. The drug is best avoided in the 1st trimester.
Excreted into breast milk in low concentrations. No reports of adverse effects in nursing infants have been located hoqwcwe manufacturer recommends to not use during breastfeeding
Oral plasma clearance of amantadine is reduced and the plasma half-life and plasma concentrations are increased in healthy elderly individuals age 60 and older
Patients with kidney problems or poor renal clearance may require a lower starting and daily dose
No increase in adverse reactions to amantadine has been observed among persons with liver disease
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Last updated August 15 2022 20:48:12. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.