Class: Nonbenzodiazepine/Pyrazolopyrimidine FDA Indications: Short-term Treatment Of Insomnia Off-Label Use: NONE
FDA Schedule IV Forms: 5, 10mg capsule Dose Range: 5-20 mg/day Starting: Start at 5 mg QHS for elderly, 10 mg QHS otherwise. High-fat/heavy meal can ↑ absorption and delay TMAX by ~2° Stopping: Taper to avoid rebound insomnia
Contraindications: None, other than patients with known hypersensitivity to zaleplon Serious Side Effects: "complex" behaviors i.e., somnambulism, sleep related eating and sleep-driving Side Effects: sedation/somnolence, dizziness, amnesia, headache
Category C—∅ studies of zaleplon in pregnant women ∴ not recommended for use during pregnancy
RID 1.5%; Probably safe. Levels in milk averaged 14 ug/liter
Start at 5mg qhs
2019 BEE℞S Recommendation: Avoid. Nonbenzodiazepine benzodiazepine receptor agonist hypnotics (ie, Z drugs) have adverse events similar to those of benzodiazepines in older adults (eg, delirium, falls, fractures); increased emergency room visits/ hospitalizations; motor vehicle crashes; minimal improvement in sleep latency and duration.
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