Class: Multimodal Antidepressant FDA Indications: MDD Off-Label Use: GAD, Cognitive Symptoms Associated With Depression, Geriatric Depression
Forms: 5, 10, 20mg tablet Dose Range: 10-20 mg/day Starting: Start 10 mg qd; can ↓ to 5 mg once daily or ↑ to 20 mg qd depending on patient response; maximum recommended dose generally 20 mg qd Stopping: Because of long t½, taper is not necessary
Contraindications: Concomitant use of MAOIs Serious Side Effects: Serotonin syndrome; ↑ risk of SI in children and young adults; may impair platelet aggregation; SIADH Side Effects: nausea (26% @ 10mg, versus 9% placebo), constipation
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