Category C—Thiothixene, a phenothiazine derivative, is structurally and pharmacologically related to trifluoperazine and chlorprothixene (see Trifluoperazine). Although occasional reports have attempted to link various phenothiazines with congenital malformations, most of the evidence suggests that these drugs are low risk for the embryo-fetus.
No reports describing the use of thiothixene during lactation have been located. The molecular weight (about 444) is low enough that excretion into breast milk should be expected. The effect on a nursing infant from exposure to the drug in milk is unknown. However, other phenothiazines are present in milk and have caused toxicity. Sedation is a possible effect in nursing infants.
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Elderly and debilitated patients should be started on lower dosage.
2019 BEE℞S Recommendation: Avoid, except in schizophrenia or bipolar disorder. Increased risk of CVA and greater rate of cognitive decline and mortality in persons with dementia. Avoid antipsychotics for behavioral problems of dementia or delirium unless nonpharmacological options have failed or are not possible and the older adult is threatening substantial harm to self or others.
No dosage adjustment necessary.
No dosage adjustment necessary.
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Last updated August 15 2022 20:48:12. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.