FDA Schedule IV Forms: 5, 10, 15, 20mg tablet Dose Range: 5-20 mg/day Starting: Recommended dose is 10 mg, 30 min prior to going to bed, with at least 7° remaining before the planned time of awakening. If the 10 mg dose is well-tolerated but not effective, the dose can be ↑'d to 20 mg
Contraindications: Do not use in patients with narcolepsy Serious Side Effects: Nighttime "sleep-driving" and other complex behaviors while out of bed and not fully awake. Risk increases with dose, with use of CNS depressants, and with alcohol. Side Effects: sedation/somnolence
Orexin, also called hypocretin, is a a peptide neurotransmitter that regulates arousal, wakefulness, and appetite. Orexins maintain arousal in response to various stimuli. There are two types of orexin: orexin-A and -B, and two receptors, OX1 and OX2, both of which are essential for maintaining a stable sleep/wakefulness cycle. Suvorexant blocks both of these receptors, inhibiting the orexins' ability to sustain wakefulness or increase arousal in motivating conditions.
FDAs recommended cautious dose ↑ in obese females with a noted ↑ in AUC and Cmax by 46% & 25%, respectively
Category C—Based on animal data, may cause fetal harm
Suvorexant & its hydroxyl-suvorexant metabolite were excreted in rat milk at levels higher (9 & 1.5 times, respectively) than that in maternal plasma. It is not known whether this drug is secreted in human milk
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Last updated May 17 2021 17:22:54. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.
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