Serious Side Effects: Can exacerbate myoclonus, but the effect is mild and does not require discontinuance of the drug Side Effects: drowsiness (18-21%), fatigue (11%), ataxia, headache, dizziness (17-28%), diplopia, nystagmus, diarrhea, tremor, peripheral edema
1° MOA: Binds to the α2δ subunit of presynaptic N and P/Q VGCCs, block the release of excitatory neurotransmitters such as glutamate when neurotransmission is excessive
- caution when prescribing with other CNS depressants; can cause respiratory depression when combined with opioids
concomitant treatment with opioids is associated with a substantial increase in the risk of opioid-related death
Maalox ↓'s bioavailability by 20%, so have patient take Neurontin at least 2 hours after Maalox
↓'s hydrocodone levels by up to 20% for unknown reasons
- surprisingly has no direct GABA-mimetic activity
relatively mild side effect profile besides sedation/fatigue
↑'s slow-wave δ sleep
apparently no potential for overdose: 1 patient took 49 grams in overdose with no serious sequelae
Category C—Limited Human Data — Animal Data Suggest Risk
RID 1.3-3.8%; Limited Human Data—Probably Compatible
No dosage adjustment necessary
CrCl ≥60 mL/min: 300-1,200 mg tid CrCl >15-59 mL/min: 200-700 mg tid CrCl 15 mL/min:100-300 mg qd CrCl <15 mL/min: ↓ dose in proportion to CrCl based on dose for CrCl of 15mL/min ESRD requires hemodialysis
Not hepatically metabolized ∴ no dose adjustments required
Developed & Designed by Kevin M. Nasky, D.O. • Built with Bootstrap, PHP & MySQL • Hosted by SiteGround
Last updated February 29 2024 20:54:18. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.
Think before you use this website!
Psychopharmacopeia.com includes clinical information intended for use by healthcare professionals. This does not constitute as clinical or professional advice. Physicians and other healthcare professionals should always use their own clinical judgment first and follow laws and guidelines in their own practice jurisdiction. Psychopharmacopeia.com does not give medical advice or diagnostic services. Neither we nor our content providers can guarantee that the content covers all possible uses, directions, precautions, drug interactions, or adverse effects that may be associated with any therapeutic treatments.
Non-health care providers who use this website, please do so at your own risk, and always seek professional medical advice. I have done my best to ensure that the information on this website is reliable, but neither we nor our content providers guarantee the accuracy of the information contained on this site.
Use this site at your own risk. Psychopharmacopeia.com and its hosting provider do not assume any liability or responsibility for damage, injury, or death to you, other persons or property from any use of any ideas, information, or instruction in this website.