Serious Side Effects: Can exacerbate myoclonus, but the effect is mild and does not require discontinuance of the drug Side Effects: drowsiness (18-21%), fatigue (11%), ataxia, headache, dizziness (17-28%), diplopia, nystagmus, diarrhea, tremor, peripheral edema
1° MOA: Binds to the α2δ subunit of presynaptic N and P/Q VGCCs, block the release of excitatory neurotransmitters such as glutamate when neurotransmission is excessive
- caution when prescribing with other CNS depressants; can cause respiratory depression when combined with opioids
concomitant treatment with opioids is associated with a substantial increase in the risk of opioid-related death
Maalox ↓'s bioavailability by 20%, so have patient take Neurontin at least 2 hours after Maalox
↓'s hydrocodone levels by up to 20% for unknown reasons
- surprisingly has no direct GABA-mimetic activity
relatively mild side effect profile besides sedation/fatigue
↑'s slow-wave δ sleep
apparently no potential for overdose: 1 patient took 49 grams in overdose with no serious sequelae
Category C—Limited Human Data — Animal Data Suggest Risk
RID 1.3-3.8%; Limited Human Data—Probably Compatible
No dosage adjustment necessary
CrCl ≥60 mL/min: 300-1,200 mg tid CrCl >15-59 mL/min: 200-700 mg tid CrCl 15 mL/min:100-300 mg qd CrCl <15 mL/min: ↓ dose in proportion to CrCl based on dose for CrCl of 15mL/min ESRD requires hemodialysis
Not hepatically metabolized ∴ no dose adjustments required
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Last updated May 17 2021 17:22:54. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.
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