Category C—A case-control study showed ∅ ↑ congenital malformations with 1st trimester use & a review (n=209) showed ∅ assoc with congenital malformations or developmental delay.
RID 1.2-3%; contraindicated d/t significant hypotonia & sedation
Avoid due to its anticholinergicity and high sedation, especially when combining with other CNS depressants and/or anticholingerics. Caution regarding orthostatic hypotension (fall risk!). Can impair cognition.
2019 BEE℞S Recommendation: At low doses (≤6 mg/day), safety profile comparable to that of placebo. At doses > 6mg, avoid d/t being highly anticholinergic, sedating, and propensity to cause orthostatic hypotension.
No dosage adjustment necessary.
All TCAs are hepatically metabolzed, highly protein bound and will accumulate, and associated with ↑ LFTs.
Developed & Designed by Kevin M. Nasky, D.O. • Built with Bootstrap, PHP & MySQL • Hosted by SiteGround
Last updated May 17 2021 17:22:54. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.