Class: SNRI FDA Indications: MDD Off-Label Use: GAD, Vasomotor Symptoms, Fibromyalgia, PTSD, Social Anxiety, Panic Disorder, PMDD
Forms: 25, 50, 100mg extended-release tablet Dose Range: 50-100 mg/day Starting: 50 mg is both a starting dose and therapeutic dose. Stopping: A gradual reduction in the dose rather than abrupt cessation is recommended whenever possible
Contraindications: Concomitant use of MAOIs Serious Side Effects: Serotonin syndrome; ↑ risk of SI in children and young adults; may impair platelet aggregation; SIADH; HTN Side Effects: nausea, dizziness, insomnia, sedation/somnolence, hyperhidrosis, constipation, decreased appetite, sexual dysfunction, anxiety
1° MOA: Serotonin norepinephrine reuptake inhibitor Target: SERT, NET
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