Category D—CBZ can cause fetal harm (spina bifida) when administered to a pregnant woman. Fetal plasma concentrations range between 50-80% of maternal levels. CBZ is cleared more rapidly in the 3rd trimester
RID 1.1-7.3%; some AEs reported, suggest discontinue or bottle feed
Clearance is age dependent, with higher clearance reported in younger children and lower clearances reported in older patients
Renal disease and dialysis do not alter clearance
Patients with significant liver disease may have a decreased clearance of carbamazepine
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Last updated August 15 2022 20:48:12. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.