Category C—The human pregnancy experience is too limited to assess the embryo-fetal risk. It is not known if phenelzine crosses the human placenta. The molecular weight of the sulfate form (about 234) and elimination half-life suggest that exposure of the embryo-fetus should be expected. The Collaborative Perinatal Project monitored 21 mother-child pairs exposed to MAO inhibitors during the 1st trimester, 3 of which were exposed to phenelzine. Three of the 21 infants had malformations (RR 2.26). Details of the three cases with phenelzine exposure were not specified.
No reports describing the use of phenelzine during breastfeeding have been located. Its molecular weight and moderately long t½ suggest that it will be excreted into breast milk.
Initial dose 7.5 mg/day; increase every few days by 7.5-15 mg/day
Elderly patients may have greater sensitivity to adverse effects.
No dose adjustment necessary
No dose adjustment necessary. The serum aminotransferase elevations that occur on phenelzine therapy are usually self-limited and mild and do not require dose modification or discontinuation of therapy.
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Last updated August 15 2022 20:48:12. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.