Category C—Fetal and/or placental concentrations similar to those in maternal plasma, generally considered by OBGYNs to be the mood stabilizer of choice during pregnancy
RID 9.2%; Limited Human Data—Potential Toxicity
Clearance is reduced by about a third in the elderly
There are no dosage adjustments required though t½ is longer in patients with renal failure
Moderate to severe impairment without ascites: ↓ initial, escalation, and maintenance doses by ~25%
Moderate to severe impairment with ascites: Decrease initial, escalation, and maintenance doses by ~50%
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Last updated August 15 2022 20:48:12. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.