Category C—No structural malformations attributable to quetiapine have been reported, the number of exposures is too low to fully assess embryo-fetal risk. There is a risk of EPS and/or withdrawal sx in the newborn if used in the 3rd trimester. Nevertheless, quetiapine is indicated for severe debilitating mental disease and the benefits to the mother appear to outweigh the potential embryo-fetal risks.
RID 0.09-0.1%; Limited Human Data—Potential Toxicity
All atypicals may increase mortality in elderly patients by 1.7 times greater than placebo. A slower rate of titration and lower target dose may be needed in elderly patients
2019 BEE℞S Recommendation: Avoid, except in schizophrenia or bipolar disorder. Increased risk of CVA and greater rate of cognitive decline and mortality in persons with dementia. Avoid antipsychotics for behavioral problems of dementia or delirium unless nonpharmacological options have failed or are not possible and the older adult is threatening substantial harm to self or others.
No dosage adjustment necessary for renal insufficiency
A slower rate of titration and lower target dose may be needed in patients with hepatic impairment
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Last updated March 09 2019 12:10:32. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.