Category C—GDM may be a problem with all SGAs; may cause extrapyramidal and/or withdrawal symptoms in neonates with third trimester exposure
All atypicals may increase mortality in elderly patients by 1.7 times greater than placebo.
2019 BEE℞S Recommendation: Avoid, except in schizophrenia or bipolar disorder. Increased risk of CVA and greater rate of cognitive decline and mortality in persons with dementia. Avoid antipsychotics for behavioral problems of dementia or delirium unless nonpharmacological options have failed or are not possible and the older adult is threatening substantial harm to self or others.
No dosage adjustment necessary.
Little pharmacokinetic Δ in severe hepatic impairment, though recommend caution and starting at lower doses (5mg) due to its sedation & anticholinergic properties
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Last updated March 09 2019 12:10:32. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.