Category D—↑ risk of oral cleft by 0.01%, use just before delivery associated with floppy infant syndrome, 3rd trimester use can cause withdrawal in newborns
Short t½ benzodiazepines such as lorazepam (RID 2.9%) are excreted into breast milk in miniscule amounts and ∴ preferred over longer-acting agents; ∅ AE's have been reported
Per Beers Criteria, should be avoided in patients ≥65 years. If used, start low 1-2 mg in divided doses.
No dosage adjustment necessary
No dose adjustment necessary with mild-moderate liver dz; use with caution if severe insufficiency