Category C—Human pregnancy experience is limited. Animal data suggest that risk to an embryo-fetus is low. Two large case-control studies did find ↑ risks for some birth defects, but the absolute risk appears to be low. A large prospective cohort that adjusted for many confounders did not find an ↑'d risk. However, SSRIs have been assoc w/ developmental toxicities, including SABs, ↓ birth weight, prematurity, neonatal serotonin syndrome, neonatal behavioral syndrome (withdrawal), respiratory distress, and PPHN
RID 3-8.3%; ∅AE's were reported in 2 case reports
Clearance values ~30% ↓ than younger controls; has been associated with cases of clinically significant hyponatremia in elderly patients
No dosing adjustment required in moderate renal impairment
10 mg is the recommended dose for most hepatically impaired patients
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Last updated March 09 2019 12:10:32. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.