Category Not assigned.—Adequate and well-controlled studies have not been conducted in pregnant women to inform drug-associated risks. May cause extrapyramidal and/or withdrawal symptoms in neonates with third trimester exposure
Lactation studies have not been conducted to assess the presence of in human milk, the effects on the breastfed infant, or the effects on milk production
All atypicals may increase mortality in elderly patients by 1.7 times greater than placebo.
2019 BEE℞S Recommendation: Avoid, except in schizophrenia or bipolar disorder. Increased risk of CVA and greater rate of cognitive decline and mortality in persons with dementia. Avoid antipsychotics for behavioral problems of dementia or delirium unless nonpharmacological options have failed or are not possible and the older adult is threatening substantial harm to self or others.
For patients with moderate, severe or end-stage renal impairment (CLcr<60 mL/min), the max recommended dosage is 2 mg qd for patients with MDD and 3 mg qd for patients with schizophrenia
For patients with moderate to severe hepatic impairment (Child-Pugh score ≥7), the max recommended dosage is 2 mg qd for patients with MDD and 3 mg qd for patients with schizophrenia
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Last updated March 25 2019 15:25:58. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.