zonisamide ZONEGRAN

Class: AED/​Mood Stabilizer
FDA Indications: Adjunct Therapy For Partial Seizures In Adults With Epilepsy
Off-Label Use: Binge Eating Disorder, Migraines, Parkinson's Disease, Neuropathic Pain, Mood Stabilization, Lewy Body Dementia
Prescribing
Forms: 25, 50, 100mg capsule
Dose Range: 100-600 mg/day
Starting: 100 mg qd, ↑ to 200 mg qd after 2 weeks, then ↑ by 100mg/d q2 weeks if necessary
Stopping: Taper; can be epileptogenic on withdrawal

NAMI drug fact sheet

Precautions
Contraindications: Allergy to sulfonamides
Serious Side Effects: Stevens-Johnson syndrome (46 per million patient-years of exposure), rash (~2%), carbonic anhydrase inhibition can cause kidney stones
Side Effects: headache, sedation/somnolence, dizziness, ataxia, nausea, anorexia, agitation, vomiting, abdominal pain, depression, difficulty concentrating, irritability, psychomotor slowing
Pharmacodynamics
1° MOA: Blockade Of Both Sodium And T-type Calcium Channels
Pharmacokinetics
t½: 63 (50-70)° TMAX: 2-6°
Substrate of: 3A4, 2D6, renal
Inhibits: ∅ ; Induces:
Active Metabolites:
DDIs
  • - 3A4 inhibitors can ↑ levels; likewise, 3A4 inducers can ↓ levels
  • - theoretically, may interact with carbonic anhydrase inhibitors & ↑ risk of kidney stones
Misc
  • - weight gain is rare, with some reports of weight loss in epilepsy trials
  • - sedation can be significant
  • - off-label use for mood stabilization not well supported by literature
  • - there is increasing evidence for a role in the treatment of both motor and nonmotor symptoms in Parkinson's Disease
Special Populations

Category C—Limited Human Data — Animal Data Suggest High Risk

Limited Human Data — Potential Toxicity


Elderly patients may be more susceptible to adverse effects

Predominantly renally cleared, use with caution; marked renal impairment (CrCl < 20 mL/min) was associated with an increase in AUC by 35%

The pharmacokinetics of zonisamide in patients with impaired liver function have not been studied

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Last updated June 10 2018 15:40:14. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.