Category C—The animal and limited human data suggest that the risk for major malformations in the embryo is low. Studies for other aspects of developmental toxicity in the embryo-fetus, however, have not been conducted.
Although the amount of trazodone in milk is very small (RID 2.8%), in 2001 the American Academy of Pediatrics classified trazodone as a drug for which the effect on nursing infants is unknown but may be of concern.
May require lower doses. Start low.
No dosage adjustment necessary.
Use with caution. Dosage adjustment required based on severity of impairment.