thiothixene NAVANE

Class: First Generation Antipsychotic/​Thioxanthene
FDA Indications: Schizophrenia
Off-Label Use: Bipolar Mania, Agitation And Aggression In Dementia, Agitation And Psychosis Due To Delirium
Prescribing
Forms: 1, 2, 5, 10, 20mg capsule; 5 mg/ml po soln; 2 mg/ml, 5 mg/ml, 10 mg/ml IM
Dose Range: 10-60 mg/day
Starting: 5-10 mg/day; maximum dose generally 60 mg/day; higher doses may be given in divided doses
Stopping: Taper 6-8 weeks, rapid d/c can lead to rebound psychosis
Monitoring:

NAMI drug fact sheet

Precautions
Contraindications: Contraindicated in severe central nervous system depression (alcohol, barbiturates, narcotics, etc.) or comatose states
Serious Side Effects: , , Neutropenia and/or Agranulocytosis (rare), Hyperprolactinemia
Side Effects: anticholinergic side effects, EPS
Pharmacodynamics
1° MOA: Dopamine 2 (D2) receptor antagonism in mesolimbic area
Target: D2 (very high), 5HT2A (low), α1 (moderate), H1 (very high), M1 (low)
Pharmacokinetics
t½: 34° TMAX: 1-3°
Substrate of: 1A2; 2D6
Inhibits: ∅ ; Induces:
Active Metabolites: N-demethylthiothixene, thiothixene sulfoxide
DDIs
Misc
  • - elimination is biphasic, with an initial t½ of 3.4 hours and a terminal t½ of 34 hours
  • - may cause less weight gain than other antipsychotics
  • - mid- to high-potency neuroleptic
  • - there are some studies supporting off-label use for agitation in dementia
Special Populations

Category C—Thiothixene, a phenothiazine derivative, is structurally and pharmacologically related to trifluoperazine and chlorprothixene (see Trifluoperazine). Although occasional reports have attempted to link various phenothiazines with congenital malformations, most of the evidence suggests that these drugs are low risk for the embryo-fetus.

No reports describing the use of thiothixene during lactation have been located. The molecular weight (about 444) is low enough that excretion into breast milk should be expected. The effect on a nursing infant from exposure to the drug in milk is unknown. However, other phenothiazines are present in milk and have caused toxicity. Sedation is a possible effect in nursing infants.

Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Elderly and debilitated patients should be started on lower dosage.

No dosage adjustment necessary.


No dosage adjustment necessary.

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Last updated August 27 2018 18:45:06. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.