FDA Schedule IV Forms: 5, 10, 15, 20mg tablet Dose Range: 5-20 mg/day Starting: Recommended dose is 10 mg, 30 min prior to going to bed, with at least 7° remaining before the planned time of awakening. If the 10 mg dose is well-tolerated but not effective, the dose can be ↑'d to 20 mg
Contraindications: Do not use in patients with narcolepsy Serious Side Effects: Nighttime "sleep-driving" and other complex behaviors while out of bed and not fully awake. Risk increases with dose, with use of CNS depressants, and with alcohol. Side Effects: sedation/somnolence
Orexin, also called hypocretin, is a a peptide neurotransmitter that regulates arousal, wakefulness, and appetite. Orexins maintain arousal in response to various stimuli. There are two types of orexin: orexin-A and -B, and two receptors, OX1 and OX2, both of which are essential for maintaining a stable sleep/wakefulness cycle. Suvorexant blocks both of these receptors, inhibiting the orexins' ability to sustain wakefulness or increase arousal in motivating conditions.
FDAs recommended cautious dose ↑ in obese females with a noted ↑ in AUC and Cmax by 46% & 25%, respectively
Category C—Based on animal data, may cause fetal harm
Suvorexant & its hydroxyl-suvorexant metabolite were excreted in rat milk at levels higher (9 & 1.5 times, respectively) than that in maternal plasma. It is not known whether this drug is secreted in human milk
Developed & Designed by Kevin M. Nasky, D.O. • Built with Bootstrap, PHP & MySQL • Hosted by SiteGround
Last updated March 25 2019 15:25:58. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.
Think before you use this website!
Psychopharmacopeia.com includes clinical information intended for use by healthcare professionals. This does not constitute as clinical or professional advice. Physicians and other healthcare professionals should always use their own clinical judgment first and follow laws and guidelines in their own practice jurisdiction. Psychopharmacopeia.com does not give medical advice or diagnostic services. Neither we nor our content providers can guarantee that the content covers all possible uses, directions, precautions, drug interactions, or adverse effects that may be associated with any therapeutic treatments.
Non-health care providers who use this website, please do so at your own risk, and always seek professional medical advice. I have done my best to ensure that the information on this website is reliable, but neither we nor our content providers guarantee the accuracy of the information contained on this site.
Use this site at your own risk. Psychopharmacopeia.com and its hosting provider do not assume any liability or responsibility for damage, injury, or death to you, other persons or property from any use of any ideas, information, or instruction in this website.