Category C—No reports describing the use in human pregnancy have been located. The animal reproduction data suggest moderate risk, but the absence of human pregnancy experience prevents an assessment of the embryo-fetal risk
RID 7%; No Human Data—Potential Toxicity
Clearance tends to ↓ with increasing age, c/w age-related ↓'s in CrCl ∴ ↓'d dose may be required in patients who have age-related compromised renal fcn
CrCl ≥60 mL/min: 300-1,200mg/d (divided BID or TID) CrCl >30-60 mL/min: 75-300mg/d (divided BID or TID) CrCl ≥15-30 mL/min: 25-150mg/d (given QD or divided BID) CrCl <15mL/min: 25-75mg/d QD (single dose)
No dose adjustment required in liver impairment
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Last updated March 25 2019 15:25:58. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.