Category C—The limited human pregnancy experience and the animal reproduction data suggest low embryo-fetal risk.
There are no reports describing use during lactation. The manufacturer reports that small amounts are excreted into human milk which is c/w prazosin's molecular weight. The effects on a nursing infant from exposure to the drug from breast milk are unknown.
Elderly patients may be more sensitive to the hypotensive and adverse effects of prazosin.
2019 BEE℞S Recommendation: Avoid use as an antihypertensive. High risk of orthostatic hypotension and associated harms, especially in older adults; not recommended as routine treatment for hypertension; alternative agents have superior risk/benefit profile.
No dosage adjustment necessary.
No specific recommendations are available for hepatic disease. Since prazosin is extensively metabolized, it is prudent to start with the lowest initial dosage (1 mg PO qhs).
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Last updated March 25 2019 15:25:58. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.