oxazepam SERAX

Class: Benzodiazepine
FDA Indications: Anxiety Disorders, Anxiety Associated With Depression, Acute Alcohol Withdrawal
Off-Label Use:
Prescribing
FDA Schedule IV
Forms: 10, 15, 30mg capsule
Dose Range: 30-120 mg/day
Starting: 10-30 mg, tid-qid

NAMI drug fact sheet

Precautions
Serious Side Effects: Overdose can result in hypotension, respiratory depression, and coma
Side Effects: headache, sedation/somnolence, dizziness, nausea, edema
Pharmacodynamics
1° MOA: GABAAR PAM
Target: GABAA: α2 (moderate) α1 (low-moderate), γ2 (low-moderate),
Pharmacokinetics
t½: 8 (5.5-10.5)° TMAX:
Absorption Rate: Slow
Lipid Solubility: Low-moderate
Substrate of: Solely via conjugation
Inhibits: ∅ ; Induces:
Active Metabolites:
DDIs
  • - CNS depression with combined use of opioids
Misc
  • - a metabolite of diazepam, prazepam, and temazepam
  • - metabolized by phase II enzymes to glucuronides and then largely renally excreted
Special Populations

Category D—↑ risk of oral cleft by 0.01%, use just before delivery associated with floppy infant syndrome, 3rd trimester use can cause withdrawal in newborns

Excreted in breast milk. Drowsiness, lethargy, or weight loss in nursing infants have been observed in case reports following maternal use of some benzodiazepines

Start low, 10 mg tid, titrate cautiously


There are no dosage adjustments provided in the manufacturer's labeling

No dosage adjustments recommended in manufacturer's labeling, however, pharmacokinetic studies have been shown that hepatic dysfunction is not expected to significantly decrease clearance.

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Last updated June 10 2018 15:40:14. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.