- nonlinear pharmacokinetics; inhibits its own metabolism
Food delays the absorption and decreases its bioavailability ~20%
very effective antidepressant
more sedating than other antidepressants, but causes less sexual side effects
Category C—Although the animal data suggest moderate risk, the limited human pregnancy experience suggests that the risk of developmental toxicity is low. However, long-term studies on functional and/ or neurobehavioral deficits have not been conducted.
RID 0.3-0.45%; Limited Human Data—Potential Toxicity
Initiate at half the usual adult dose, and then follow same titration schedule as younger patients
No adjustments necessary
Contraindicated in patients with known hepatic impairment
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Last updated March 25 2019 15:25:58. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.
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