Category C—No reports describing the use of iloperidone in human pregnancy have been located. However, there is a risk of extrapyramidal and/ or withdrawal symptoms in the newborn with atypical antipsychotics if they are used in the 3rd trimester.
It is not known if iloperidone is excreted in breast milk. Breast-feeding is not recommended by the manufacturer.
All atypicals may increase mortality in elderly patients by 1.7 times greater than placebo; caution in elderly due to its strong α1 activity and orthostasis and associated fall risk
2019 BEE℞S Recommendation: Avoid, except in schizophrenia or bipolar disorder. Increased risk of CVA and greater rate of cognitive decline and mortality in persons with dementia. Avoid antipsychotics for behavioral problems of dementia or delirium unless nonpharmacological options have failed or are not possible and the older adult is threatening substantial harm to self or others.
There are no dosage adjustments required
Mild-moderate impairment: No dosage adjustment necessary. Severe hepatic impairment: Use is not recommended.
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Last updated March 25 2019 15:25:58. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.