Class: SSRI FDA Indications: OCD Off-Label Use: Depression, Bulimia Nervosa, PTSD, Social Anxiety, Panic Disorder
Forms: 25, 50, 100mg tablet Dose Range: 50-300 mg/day Starting: Start at 50 mg qd then ↑ by 50 mg increments q4-7 days, usual dose range 100-300mg qd Stopping: A gradual reduction in the dose rather than abrupt cessation is recommended whenever possible
Contraindications: Concomitant use of MAOIs Serious Side Effects: Serotonin syndrome; ↑ risk of SI in children and young adults; may impair platelet aggregation; SIADH Side Effects: headache, sedation/somnolence, dizziness, weakness/asthenia, anorgasmia, xerostomia, diarrhea, nausea, insomnia, anorexia, anxiety
t½: 16 (9-28)° TMAX: 1.5-8° Substrate of: 1A2, 2D6 Inhibits: 1A2 & 2C19 (potent, even at low doses), 2B6, 2C9 & 3A4 (moderate), 2D6 (weak); Induces: ∅ Active Metabolites: ∅
- a veritable "pan-inhibitor," possible interactions via CYP inhibition are legion
particular attention should be paid to other drugs with narrow therapeutic indices e.g. theophylline, warfarin, phenytoin & 3° TCAs; be cautious when adding any drug to fluvoxamine–"Start low, go slow!"
caffeine is also a 1A2 substrate, so Luvox can make that morning cup of coffee a lot more stimulating!
a 1A2 substrate itself, its own concentrations can be decreased by cigarette smoke's 1A2 induction
nonlinear pharmacokinetics; inhibits its own metabolism
- σ1R properties may explain rapid-onset effects on anxiety & insomnia, and pro-cognitive effects in treatment of psychotic depression & schizophrenia
- may have ↓ sexual SEs than other SSRIs
- can be cautiously combined with clomipramine for treatment-resistant OCD
- considered to be the "weight neutral" SSRI
- actually ↓'s QTc by -5 msec
Category C—A case study of 26 infants exposed to fluvoxamine in utero reported that exposure was not associated with increased risk of malformations, lower birth weights, or younger gestational age.
Developed & Designed by Kevin M. Nasky, D.O. • Built with Bootstrap, PHP & MySQL • Hosted by SiteGround
Last updated March 25 2019 15:25:58. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.
Think before you use this website!
Psychopharmacopeia.com includes clinical information intended for use by healthcare professionals. This does not constitute as clinical or professional advice. Physicians and other healthcare professionals should always use their own clinical judgment first and follow laws and guidelines in their own practice jurisdiction. Psychopharmacopeia.com does not give medical advice or diagnostic services. Neither we nor our content providers can guarantee that the content covers all possible uses, directions, precautions, drug interactions, or adverse effects that may be associated with any therapeutic treatments.
Non-health care providers who use this website, please do so at your own risk, and always seek professional medical advice. I have done my best to ensure that the information on this website is reliable, but neither we nor our content providers guarantee the accuracy of the information contained on this site.
Use this site at your own risk. Psychopharmacopeia.com and its hosting provider do not assume any liability or responsibility for damage, injury, or death to you, other persons or property from any use of any ideas, information, or instruction in this website.