Category D—Limited reports describing the use of flurazepam in human pregnancy have been located. The effects of this drug on the fetus should be similar to other benzodiazepines, including the risk of malformations after exposure in the 1st trimester. Maternal use near delivery may cause a syndrome of hypothermia, hypotonia, respiratory depression, withdrawal, and difficulty feeding. The manufacturer classifies flurazepam as contraindicated in pregnancy.
Low incidence of infant toxicity and AEs associated with benzodiazepine use during breastfeeding. Benzodiazepines with shorter half-lives (i.e., lorazepam, alprazolam, and oxazepam) have been found to be very low in breast milk
In most elderly patients, the slow accumulate of the desalkyl metabolites causes a morning-after cognitive impairment
2019 BEE℞S Recommendation: Avoid. Older adults have increased sensitivity to benzodiazepines and decreased metabolism of long- acting agents; in general, all benzodiazepines increase risk of cognitive impairment, delirium, falls, fractures, and motor vehicle crashes in older adults. May be appropriate for seizure disorders, RBD, benzodiazepine withdrawal, EtOH withdrawal, severe GAD, and periprocedural anesthesia.
Renal insufficiency has a quantitatively small influence on pharmacokinetics; no dosage adjustments provided in the manufacturer's labeling
T½ ↑ ≈ 73% in patients with alcohol liver disease
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Last updated March 25 2019 15:25:58. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.