Category C—Third-trimester use can result in EPS or withdrawal symptoms in the newborn. Although one case report described multiple anomalies, most evidence suggests that phenothiazines are relatively low risk during pregnancy
No Human Data–Potential Toxicity
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.
2019 BEE℞S Recommendation: Avoid, except in schizophrenia or bipolar disorder. Increased risk of CVA and greater rate of cognitive decline and mortality in persons with dementia. Avoid antipsychotics for behavioral problems of dementia or delirium unless nonpharmacological options have failed or are not possible and the older adult is threatening substantial harm to self or others.
No dosage adjustment necessary.
No dosage adjustment necessary
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Last updated March 25 2019 15:25:58. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.