Category C—Human Data Suggest Risk in 3rd Trimester
Start at a 30 mg qd for 2 weeks before considering ↑ to 60 mg target dose; watch for hypoNa+ at doses > 60 mg in the elderly
Avoid use in patients with severe renal impairment, GFR <30 mL/min
Avoid use in patients with chronic liver disease or cirrhosis
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Last updated March 25 2019 15:25:58. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.