Category C—The lack of teratogenicity in animals and the absence of a clustering of similar birth defects in human pregnancies exposed to disulfiram suggest that this drug is not a major human teratogen. Obviously, women taking disulfiram should not drink alcohol, but this is occasionally the case because of the findings of fetal alcohol syndrome and defects that are suggestive of fetal alcohol exposure.
No reports describing the use of disulfiram during lactation have been located. Because of the relatively low molecular weight, excretion into milk should be expected. The potential effect of this exposure on a nursing infant is unknown.
Cardiovascular tolerance decreases with age, thus increasing severity of alcohol reactions
Contraindicated in severe renal disease
If baseline transaminase levels are normal or only moderately elevated (less than five times the upper limit of normal), use with careful monitoring of liver function.
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Last updated February 07 2019 16:52:18. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.