Category D—The effects of benzodiazepines on the human embryo and fetus are controversial. Although some studies have reported an association with various types of congenital defects, other studies have not found such associations. Maternal denial of exposure and concurrent exposure to other toxic drugs and substances (e.g., alcohol and smoking) may be confounding factors. If the maternal condition requires use of the drug during pregnancy, the lowest possible dose should be taken.
No reports describing the use of clorazepate during human lactation have been located. Other benzodiazepines accumulate in human milk, and adverse effects in the nursing infant have been reported. In 2001, the American Academy of Pediatrics classified other benzodiazepines as drugs whose effect on the nursing infant is unknown but may be of concern.
2019 BEE℞S Recommendation: Avoid. Older adults have increased sensitivity to benzodiazepines and decreased metabolism of long- acting agents; in general, all benzodiazepines increase risk of cognitive impairment, delirium, falls, fractures, and motor vehicle crashes in older adults. May be appropriate for seizure disorders, RBD, benzodiazepine withdrawal, EtOH withdrawal, severe GAD, and periprocedural anesthesia.
No dosage adjustment necessary
No dose adjustment necessary with mild-moderate liver dz; use with caution if severe insufficiency
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Last updated March 25 2019 15:25:58. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.