Class: SSRI FDA Indications: MDD Off-Label Use: Binge Eating Disorder, GAD, Vasomotor Symptoms Of Menopause, OCD, Pathological Gambling, Premature Ejaculation, Fibromyalgia, Agitation In Alzheimers Disease
Forms: 10, 20, 40mg tablet; 10mg/5mL po soln Dose Range: 10-60 mg/day Starting: Start at 20 mg qd, ↑ dose by 20 mg q3 weeks; efficacy with doses >40 mg has not been demonstrated in clinical trials and doses >40 mg not recommended due to risk of ↑ QT interval Stopping: Gradually taper the dose to minimize the incidence of withdrawal symptoms and allow for the detection of re-emerging symptoms
Contraindications: Concomitant use of MAOIs, patients with congenital long QT, Concomitant use in patients taking pimozide Serious Side Effects: Serotonin syndrome; ↑ risk of SI in children and young adults; may impair platelet aggregation; SIADH Known Risk of TdP Side Effects: sedation/somnolence, anorgasmia, xerostomia, hyperhidrosis, tremor, diarrhea, nausea
1° MOA: Selective Serotonin Reuptake Inhibitor Target: SERT
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