Category C—May cause extrapyramidal and/or withdrawal symptoms in neonates with third trimester exposure
Lactation studies have not been conducted to assess the presence of asenapine in human milk
All atypicals may increase mortality in elderly patients by 1.7 times greater than placebo.
2019 BEE℞S Recommendation: Avoid, except in schizophrenia or bipolar disorder. Increased risk of CVA and greater rate of cognitive decline and mortality in persons with dementia. Avoid antipsychotics for behavioral problems of dementia or delirium unless nonpharmacological options have failed or are not possible and the older adult is threatening substantial harm to self or others.
There are no dosage adjustments required
Contraindicated in patients with severe hepatic impairment; no dosage adjustment required in mild to moderate hepatic impairment
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Last updated March 25 2019 15:25:58. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.