Contraindications: Not recommended for use in patients with a h/o LVH, ischemic ECG Δ's, chest pain, arrhythmias or recent MI Serious Side Effects: ∅ Side Effects: xerostomia, diarrhea, nausea, insomnia, anxiety, palpitations, rhinitis/rhinorrhea, hypertension, headache (14-23%)
1° MOA: Exact mechanism of action is unknown, but it is believed that the increase in synaptic dopamine following blockade of DAT leads to increased tonic firing and downstream effects on neurotransmitters including those involved in wakefulness, such as histamine and orexin/ hypocretin Target: DAT, D2 partial agonist
the R and S enantiomers elicit similar effects, but the R enantiomer is more potent and delivers a longer effect
novel mechanism of action and therapeutic uses with less abuse potential, but is often classified as a stimulant
α1 antagonists (e.g., prazosin) may block its therapeutic actions
may be useful in treating fatigue in patients with depression, multiple sclerosis, myotonic dystrophy and HIV/AIDS
subjective sensation is generally normal wakefulness, not stimulation, but can occasionally include jitteriness
may induce its own metabolism at high doses via 3A4 induction
Category Undefined.—Animal data suggest moderate risk, but limited human pregnancy experience prevents a full assessment of risk. Avoiding modafinil during pregnancy is the best course, but inadvertent exposure does not appear to represent a major risk of embryo-fetal harm
No reports describing the use of modafinil during human lactation have been located
Clearance of modafinil may be reduced in the elderly
There is inadequate information to determine safety and efficacy of dosing in patients with severe renal impairment
Dose should be reduced in patients with severe hepatic impairment
Developed & Designed by Kevin M. Nasky, D.O. • Built with Bootstrap, PHP & MySQL • Hosted by SiteGround
Last updated February 07 2019 16:52:18. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.
Think before you use this website!
Psychopharmacopeia.com includes clinical information intended for use by healthcare professionals. This does not constitute as clinical or professional advice. Physicians and other healthcare professionals should always use their own clinical judgment first and follow laws and guidelines in their own practice jurisdiction. Psychopharmacopeia.com does not give medical advice or diagnostic services. Neither we nor our content providers can guarantee that the content covers all possible uses, directions, precautions, drug interactions, or adverse effects that may be associated with any therapeutic treatments.
Non-health care providers who use this website, please do so at your own risk, and always seek professional medical advice. I have done my best to ensure that the information on this website is reliable, but neither we nor our content providers guarantee the accuracy of the information contained on this site.
Use this site at your own risk. Psychopharmacopeia.com and its hosting provider do not assume any liability or responsibility for damage, injury, or death to you, other persons or property from any use of any ideas, information, or instruction in this website.