Category C—The limited animal and human data suggest that sertraline is not a major teratogen. Appears to result in least placental exposure. Two large case-control studies did find increased risks for some birth defects, but the absolute risk appears to be small. However, SSRIs have been associated with several developmental toxicities, including spontaneous abortions, low birth weight, preterm delivery, neonatal serotonin syndrome, neonatal behavioral syndrome (withdrawal), possible sustained abnormal neurobehavior beyond the neonatal period, respiratory distress, and persistent pulmonary hypertension of the newborn (PPHN).
Considered to be 1st-line drug for BF women, with a low RID, ranging from 0.5-3%; very few AEs described in the literature
Avoid use in patients ≥65 with a history of falls or fractures
No dosage adjustment necessary.
↓ dose 50% even in mild impairment. DO NOT USE if moderate-severe impairment.
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Last updated March 25 2019 15:25:58. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.