Category C—Can't be recommened. Few data supporting its safety.
Clearance ↓'d by as much as 40% in patients >55
↓'d clearance & ↑'d AUC, (54 % & 215 % for moderate & severe impairment, respectively).
Use with caution. t½ ↑'d by 40% in mild to moderate hepatic impairment.