Category C—Has the most data supporting its safety.
Highest RID (1.6-14.6%) among the SSRIs; ∅AE's have been reported for majority of fluoxetine-exposed infants; conflicting reports about effects on growth curves
Start low with dosage ↑ of 10 & 20 mg q several weeks; can cause agitation, sleep disturbances, & ↑CNS stimulation in elderly.
Use with caution in patients with severe renal impairment
Administer a lower dose or less frequent dosing interval due to long t½