Category C—The limited human pregnancy experience and the animal reproduction data suggest low embryo-fetal risk.
There are no reports describing use during lactation. The manufacturer reports that small amounts are excreted into human milk which is c/w prazosin's molecular weight. The effects on a nursing infant from exposure to the drug from breast milk are unknown.
Elderly patients may be more sensitive to the hypotensive and adverse effects of prazosin.
No dosage adjustment necessary.
No specific recommendations are available for hepatic disease. Since prazosin is extensively metabolized, it is prudent to start with the lowest initial dosage (1 mg PO qhs).