Category C—Apparently not a teratogen, but fetal and neonatal toxicity may occur. Some β-blockers may cause IUGR & ↓'d placental weight (treatment beginning early in the 2nd trimester results in the greatest weight reductions, whereas treatment restricted to the 3rd trimester primarily affects only placental weight)
RID 1%; the American Academy of Pediatrics classified propranolol as compatible with breastfeeding, though the American Academy of Pediatrics classified propranolol as compatible with breastfeeding, though nursing infants exposed to propranolol in breast milk should be closely observed for symptoms of β-blockade
Propranolol is one of the known orally-administered drugs that exhibits ↓ in first-pass metabolism with aging ∴ start low & taper cautiously
Studies have reported a delayed absorption rate and a reduced half-life of propranolol in patients with renal failure of varying severity. Use with caution.
Propranolol is extensively metabolized by the liver. Use with caution.