Category D—↑ risk of oral cleft by 0.01%, use just before delivery associated with floppy infant syndrome, 3rd trimester use can cause withdrawal in newborns
Short t½ benzodiazepines such as lorazepam (RID 2.9%) are excreted into breast milk in miniscule amounts and ∴ preferred over longer-acting agents; ∅ AE's have been reported
Per Beers Criteria, should be avoided in patients ≥65 years. If used, start low 1-2 mg in divided doses.
2019 BEE℞S Recommendation: Avoid. Older adults have increased sensitivity to benzodiazepines and decreased metabolism of long- acting agents; in general, all benzodiazepines increase risk of cognitive impairment, delirium, falls, fractures, and motor vehicle crashes in older adults. May be appropriate for seizure disorders, RBD, benzodiazepine withdrawal, EtOH withdrawal, severe GAD, and periprocedural anesthesia.
No dosage adjustment necessary
No dose adjustment necessary with mild-moderate liver dz; use with caution if severe insufficiency
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Last updated March 25 2019 15:25:58. Disclaimer: This website does not provide medical advice, nor is it a substitute for clinical judgment.